Issue #132Dec 2022 Leaders The world aheadby Bianco PialuisaWidescreen Dark tourismby Mona MarcoTalking heads A regime's fallby Editorial team LongitudeSmart thinking The enigma of decision makingby Broggi DaniloFuture cities The city of tomorrowby Incalza Ercole Towards urban regenerationby Lebruto UmbertoWorld Wide Web Big Tech's midlife crisisby Verga Enrico Of smoke and mirrorsby Corcione Carlo21st century challenges What's good about bad daysby Salzano PasqualeOccam's razor Next generation cancer immunotherapyby Serlupi Crescenzi OttavianoSpace race The Space orchestraby Tantardini MarcoTech Talk The energy trilemma and technology advancesby Paliani AndreaPotomac watch The risk of an inconclusive warby Cianfanelli RenzoFeatured briefing Is there room for talks?by Cingolani Stefano Tricky negotiationsby Jean Carlo Towards the 2024 presidential raceby Nardini Alia K.Warming bloopers The milk of human kindnessby Clini CarloChosen words Bureaucracyby Stefanini MaurizioNumbers Breadfruitby Bini FedericoCover story The wonders of advanced therapiesby Rasi Guido Shouldering the weightby Joveneau Marie The burden of rare diseasesby Corbellini Gilberto Betting on innovationby Confalone Valentino Pricing prodigiesby Joveneau Marie Going beyond the pillby Ansalone Gianluca The mirror of health and diseaseby Garcovich Simone